The role of the ubiquitin pathway in a variety of developmental processing. Currently, students in my lab are investigating the role of ubiquitin and the proteasome in the elimination of sperm organelles after fertilization.
G. Skibinski, and L. Boyd (2012) Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans. BMC Cell Biology, 13 (1)10.
S. Al Rawi, S. Louvet-Vallee, A. Djeddi, M. Sachse, E. Culetto, C. Hajjar, L. Boyd, R. Legouis, and V. Galy (2011) Post-fertilization autophagy of sperm organelles prevents mitochondrial heteroplasmy. Science. 334, pp. 1144-1147.
L. Boyd, C. Hajjar, and K. O'Connell (2011) Time-lapse microscopy of early embryogenesis in Caenorhabditis elegans. Journal of Visualized Experimentation 54. e2582.
R. Howard, P. Sharma, C. Hajjar, K. Caldwell, G. Caldwell, R. du Brueil, R. Moore, and L. Boyd (2007) Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. BMC Cell Biology 8:32 .
Y. Hao, L. Boyd, and G. Seydoux (2006) Stabilization of cell polarity by the C. elegans RING protein PAR-2. Developmental Cell 10 pp. 199-208.
M. Gudgen, A. Chandrasekaran, T. Frazier, and L. Boyd (2004) Interactions within the ubiquitin pathway of Caenorhabditis elegans. Biochemical and Biophysical Research Communications 325 pp. 479–486.
T. Frazier, D. Shakes, U. Hota, and L. Boyd(2004)C. elegans UBC-2 functions with the anaphase promoting complex and has other non-APC related activities. Journal of Cell Science 117 pp. 5427-5435.
R. Moore, and L. Boyd (2003) Analysis of RING finger proteins required for embryogenesis in C. elegans Genesis. 38 pp. 1-12.
GRADUATE STUDENT PROJECTS IN THE BOYD LAB:
Paola Molina, Molecular Biosciences Ph.D. program: RNAi screen for genes involved in ubiquitination of sperm organelles.
Katherine Sampuda, MSPS program: Activity of the sperm proteasome.
Jacob Sanders, MS Biology: Localization of ubiquitin in muscle cells.