(1999) Ph.D., University of Louisville (1993). He is currently teaching CHEM 625 (focusing on protein structure and enzymology) and CHEM 325 Biochemistry. His research interests include the mechanism of action of the enzyme DNA topoisomerase II, as well as the mechanism of action of the diverse group of anticancer drugs which target this enzyme. Dr. Burden is currently a Special Fellow of the Leukemia Society of America, and has spent the past five years as a Research Fellow in the laboratory of Dr. Neil Osherhoff in the Dept. of Biochemistry at Vanderbilt University.
Dr. Burden enjoys music, reading, and military history ( particularly the American Civil War). He has two sons: Drew, age 8, and Cassidy, age 4.
Wilson Byl, J.A., Fortune, J.M. Burden, D.A., Nitiss, J.L., Utsugi, T., Yamada, Y., and Osheroff, N. "DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement", Biochemistry 38, 15573-15579 ( 1999).
Kingma, P.S., Burden, D.A., and Osheroff, N. "Binding of Etoposide to Topoisomerase II in the Absence of DNA: Decreased Affinity as a Mechanism of Drug Resistance", Biochemistry 38, 3457-3461 ( 1999).
Burden, D.A., and Osheroff, N. "In Vitro evolution of Preferred Topoisomerase II DNA Cleavage Sites", J. Biol. Chem. 274, 5227-5235 ( 1999).
Burden D.A., Froelich-Ammon, S.J., and Osheroff, N. "Topoisomerase II-Mediated Cleavage of Plasmid DNA, " in Protocols for DNA Topoisomerases: II. Enzymology and Topoisomerase-Targeted Drugs, Bjornsti, M.A., and Osheroff, N. (eds.) Humana Press, Totowa, New Jersey, text in press.