<img height="223" border="" width="210" alt="Dr. Paul C. Kline" src="http://www.mtsu.edu/chemistry/images/kline.jpg" align="right" /><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><strong>CONTACT INFO:</strong><br /><br /> <span style="color:#333333;"><strong>E-mail:</strong></span> <a href="mailto:%20pkline@mtsu.edu">pkline@mtsu.edu</a></span><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><br /> <strong><span style="color:#333333;">Phone:</span></strong> (615)</span> <span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">898-5466</span><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><br /> <span style="color:#333333;"><strong>Office:</strong></span> Davis Science Bldg. 235<br /> <strong><span style="color:#333333;">P.O. Box</span></strong>: X102</span>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><strong>EDUCATION/INTERESTS:</strong><br /><br /> (1994) B.S., Christian Brothers College; M.S., Georgia Institute of Technology; Ph.D., University of Notre Dame; Postdoctoral, Albert Einstein College of Medicine. Bioorganic and Biophysical Chemistry: mechanistic enzymology and transition state analysis of enzyme-catalyzed reactions.</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><strong>SELECTED PUBLICATIONS:</strong></span></p>
<p class="MsoNormal"><span style="font-family:Verdana; font-size:12px;">Kline, P.C.; Noll, B.C.; Zhao, H.; Serianni, A.S. 1-(</span><span style="font-size:12px;"><span style="font-family: Verdana;">b</span><span style="font-family:Verdana;">-D-Erythrofuranosyl)cytidine (</span><span style="font-family: Verdana;">b</span></span><span style="font-family:Verdana; font-size:12px;">-erythrocytidine). <em>Acta Crystallographica Section C Crystal Structure Communications</em> 2007, C63, 137-140.</span></p>
<p class="MsoNormal"><span style="font-family:Verdana; font-size:12px;">Bates C.; Z. Kendrick Z.; McDonald, N; Kline, P. C. Transition State Analysis of Adenosine Nucleosidase from Yellow Lupin (<em>LupinuslLuteus</em>). <em>Phytochemistry</em> 2006, 67, 5-12.</span></p>
<p class="MsoNormal"><span style="font-family:Verdana; font-size:12px;">Hunt, C.; Gillani, N.; Farone, A.; Rezaei, M.; Kline, P.C. Kinetic Isotope Effects of Nucleoside Hydrolase from <em>Escherichia coli</em>. <em>Biochim. Biophys. Acta</em> <em>Proteins and Proteomics</em> 2005, 1751, 140-149.</span></p>
<p class="MsoNormal"><span style="font-family:Verdana; font-size:12px;">Abusamhadneh, E.; McDonald, N. E.; Kline, P. C. Purification and characterization of adenosine nucleosidase form yellow lupin (<em>Lupinus luteus</em>). <em>Plant Sci.</em> 2000, 153, 25-32.</span></p>
<p class="MsoNormal"><span style="font-family:Verdana; font-size:12px;">Verdel, E. F.; Kline, P. C.; Wani, S.; Woods, A. E. Purification and partial characterization of haloperoxidase from fresh water algae <em>Cladophora glomerata</em>. <em>Comp. Biochem. Physiol. B</em> 2000, 125, 179-187.</span></p>
<p class="MsoNormal"><span style="font-family:Verdana; font-size:12px;">Kline, P. C.; Razaei, M.; Lee, T. A. Determination of Kinetic Isotope Effects for Nucleoside Hydrolases using Gas Chromatography/Mass Spectrometry. <em>Anal. Biochem.</em> 1999, 275, 6-10.</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><strong>THESES AND DISSERTATIONS</strong></span></p>
<p><strong><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">DIRECTED DISSERTATIONS:</span></strong></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Mansoureh Rezaei, “Transition State Analysis of Thymidine Phosphorylase from E. coli” D.A. Dissertation 2001</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Barbara J. Walton, "Selection, Modification, and Evaluation of Laboratory Experiments for a One-Semester Introductory Biochemistry Course" D.A. Dissertation 1998.</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Nancy McDonald, "Characterization of Adenosine Nucleosidase from Lupinus Luteus" D.A. Dissertation 1998.</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;"><strong>THESES:</strong></span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Michael Kearney, "Kinetic Isotope Effects of Thymidine Phosphorylase" M.S. Thesis 1998.</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">X. Liu, "Characterization of Adenosine Nucleosidase from Yellow Lupin Seeds" M.S. Thesis 1998.</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Fariborz Rohakhtar, "Investigation of the Structure of a Stable Complex Between Purine Nucleoside Phosphorylase and Hypoxanthine," M.S. 1997.</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">E. Abusamhadneh, "Isolation and Characterization of Adenosine Nucleosidase from Yellow Lupin Seeds" M.S. Thesis 1997.<br /><br /> <strong>GRANTS:</strong></span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">Technology Access Fee Grant, “Upgrade of Biochemistry Teaching Laboratories” 2003, $170,000</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">American Chemical Society Petroleum Research Fund, "Transition State Analysis of Adenosine Nucleosidase" 1998-2000, $30,000.</span></p>
<p><span style="font-family:Verdana, Arial, Helvetica, sans-serif; font-size:12px;">P. C. Kline and A. Friedli, MTSU Technology Access Fees to purchase Gas Chromatographs for Undergraduate Organic and Biochemistry Laboratories. $40,000.</span></p>